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Receptor-mediated degradation of insulin in isolated rat adipocytes: Formation of a degradation product slightly smaller than insulin

โœ Scribed by Ole Sonne


Book ID
119120484
Publisher
Elsevier Science
Year
1987
Tongue
English
Weight
423 KB
Volume
927
Category
Article
ISSN
0167-4889

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Receptor-mediated internalization and degradation of insulin-like growth factors, IGF-I and IGF-11, were studied in primary cultures of neonatal rat astrocytes. Surface-bound IGF-I1 was rapidly internal-ize& and 80% of cell-associated radioactivity was located intracellularly after 30 min. IGF-I was