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Receptor for advanced glycation end products is upregulated in optic neuropathy of Alzheimer’s disease

✍ Scribed by Michelle Y. Wang; Fred N. Ross-Cisneros; Divya Aggarwal; Chiao-Ying Liang; Alfredo A. Sadun


Publisher
Springer-Verlag
Year
2009
Tongue
English
Weight
568 KB
Volume
118
Category
Article
ISSN
0001-6322

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Multiligand receptor for advanced glycation end products (RAGE) is expressed in a wide variety of tissues, including the liver. Interactions with its ligands lead to cellular activation and thus prolonged inflammation and apoptosis. RAGE also exists in a soluble, truncated isoform called soluble RAG