Receptor for advanced glycation end products and its ligands: Initiators or amplifiers of joint inflammation—A bit of both?

Acute Kawasaki disease is associated wit

Acute Kawasaki disease is associated with reverse regulation of soluble receptor for advance glycation end products and its proinflammatory ligand S100A12

✍ Helmut Wittkowski; Keiichi Hirono; Fukiko Ichida; Thomas Vogl; Fei Ye; Xing Yanl 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 174 KB 👁 1 views

## Abstract ## Objective Receptor for advanced glycation end products (RAGE) serves as a pattern recognition receptor for several endogenous ligands that are potent inducers of inflammation. By activating endothelial cells and leukocytes, RAGE augments recruitment of leukocytes to sites of inflamm