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Receptor binding characteristics of [3H]NAD-299, a new selective 5-HT1A receptor antagonist

✍ Scribed by Eva Jerning; Gun Torell Svantesson; Nina Mohell

Book ID
114016664
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
148 KB
Volume
360
Category
Article
ISSN
0014-2999

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A new 5-HTIA receptor antagonist ligand, [3H]p-MPPF, 4-(2'-methoxy-)phenyl-l-[2'-(N-2-pyridyl)-p-fluorobenzamido]ethyl-piperazine, was prepared and characterized. It demonstrated high affinity and selectivity toward 5-HTlA receptors (& = 0.34 t 0.12 nM and B, , = 145 t 35 fmol/mg protein in rat hip