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Receptor binding, antagonist, and withdrawal precipitating properties of opiate antagonists

✍ Scribed by Rita J. Valentino; Jonathan L. Katz; Fedor Medzihradsky; James H. Woods


Book ID
118941842
Publisher
Elsevier Science
Year
1983
Tongue
English
Weight
640 KB
Volume
32
Category
Article
ISSN
0024-3205

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Effect of NMDA receptor antagonist on na
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The ability of NMDA antagonist MK-801 to block the expression of opioid-like withdrawal signs was examined in bile duct-ligated mice and the signs were compared with sham operated and unoperated animals. Administration of MK-801 (0/1 mg/kg), 10 min prior to naloxone challenge, significantly reduced