Recent Trends in Regeneration Research

✍ Scribed by Marcus Singer, Jacqueline Géraudie (auth.), V. Kiortsis, S. Koussoulakos, H. Wallace (eds.)

• Publisher: Springer US
• Year: 1989
• Tongue: English
• Leaves: 480
• Series: NATO ASI Series 172
• Edition: 1
• Category: Library

✦ Synopsis

Regeneration, i.e. the replacement of lost body parts by new outgrowths or by remodelling existing tissues, has been studied for centuries. However, in recent years important developments took place in this field too, owing to new soph­ isticated techniques and to novel theoretical concepts. Advances in Molecular Genetics, Biochemistry, Cell and Neurobiology, Immunology, to mention a few of them, are the main causes of this resurgence of interest in regeneration. As a consequence, more and more meetings and pUblications are devoted, either exclusively or for a large part, to basic and applied research of regenerative processes. "Regeneration­ ists" scattered in laboratories allover the world and accus­ tomed to know each other through exchange of reprints - occa­ sionally an encounter in a large conference - tend now to form small groups, even societies and to institutionalize their meetings. Although the critical mass of scientists involved in regeneration research does not seem yet to be reached, for an autonomous development of this sector, regular and frequent meetings of experts appear useful, even necessary. Such a meeting was convened in Saronis, near Athens, Greece, from 19 to 23 September 1988 and sponsored by the NATO Science Committee and the University of Athens. The present volume contains the contributions to this Advanced Research Workshop on "Recent Trends in Regeneration Research". About 50 biologists from different countries, either mem­ bers of the Alliance or outside it (U.R.S.S., India, Egypt, Switzerland, Sweden) took part, mostly as invited speakers.

✦ Table of Contents

Front Matter....Pages i-xi
An Overview of the Historical Origin of the Nerve Influence on Limb Regeneration....Pages 1-5
Front Matter....Pages 7-7
Identification of a Homeobox Gene and a Keratin Pair Expressed in Amphibian Limb Regeneration....Pages 9-15
An Examination of Heat Shock and Trauma-Induced Proteins in the Regenerating Forelimb of the Newt, Notophthalmus Viridescens ....Pages 17-25
C- Myc Proto-Oncogene Expression During Newt Limb Regeneration....Pages 27-35
Expression of the WE3 Antigen in the Newt Wound Epithelium....Pages 37-49
Front Matter....Pages 55-55
How Many Populations of Cells Occur in the Mesenchymal Blastema?....Pages 57-68
Protein Kinase C Activity During Limb Regeneration of Amphibians....Pages 69-79
Production of Growth Factors by the Blastema During Limb Regeneration of Urodeles (Amphibia)....Pages 81-96
Second Messengers in Newt Limb Regeneration: cAMP and cGMP Levels and Distribution....Pages 97-105
Epimorphic Regeneration and the Immune System....Pages 107-119
Immune System and Regeneration....Pages 121-128
Dependence of Erythroblast Proliferation and Differentiation Manner in Mice Hemopoietic Tissue Regeneration on Lymphoid-Macrophagal System Cells....Pages 129-130
Insulin Localization in the Pancreas and in Forelimb Regenerates of the Adult Newt, Notophthalmus Viridescens ....Pages 131-133
Lens and Limb Regeneration in Amphibia under the Space Flight Conditions....Pages 135-136
In Vitro Effects of a Mitogenic Factor on Xenopus Laevis Forelimb Regeneration....Pages 137-140
Front Matter....Pages 145-145
Some Aspects of Regeneration in Skeletal and Cardiac Muscle....Pages 147-157
Image Analysis of Proliferation and Fusion in Cultured Satellite Cells....Pages 159-168
Regeneration of Skeletal Muscle Fibers by In Vitro Multiplied Autologous Satellite Cells....Pages 169-171
“ In Vitro ” Potentialities of Myogenic Cells Isolated from Adult Urodele Muscles....Pages 173-174
Front Matter....Pages 177-177
Mechanisms Controlling Directed Axon Regeneration in the Peripheral and Central Nervous Systems of Amphibians....Pages 179-190
Front Matter....Pages 177-177
Response of Amputated Xenopus Laevis Forelimbs to Augmentation of the Nerve Supply....Pages 191-203
Neural Influence on the Extracellular Matrix During Blastema Formation....Pages 205-215
Effects of Denervation on the Extracellular Collagen Matrix of Limb Regenerate of the Newt, Pleurodeles Waltlii ....Pages 217-227
A Quantitative Study of Innervation in Newt Multiple Limbs: Nerve Fibre Counts in Multiple Limbs Produced from Either Limb Buds or Mature Regenerating Limbs....Pages 229-236
The Origins of Spinal Ganglia in the Amphibian Tail....Pages 237-249
The Role of Nerves in Accessory Limb Development....Pages 251-261
Rapid Neuronal and Glial Changes in the Phrenic Nucleus Following Spinal Cord Injury: A Possible Morphological Basis for the Unmasking of Functionally Ineffective Synapses....Pages 263-273
Mechanisms of Transdifferentiation of Pigment Epithelial Cells into Neural Retina: A Hypothesis....Pages 275-280
Regeneration of the Central Nervous System of the Ascidian Ciona Intestinalis ....Pages 281-287
Neuropeptides Control Regeneration in Planarians....Pages 289-290
Front Matter....Pages 293-293
The Use of Retinoids to Explore the Cellular and Molecular Basis of Positional Memory in Regenerating Amphibian Limbs....Pages 295-311
Biochemical Pathways Involved in the Respecification of Pattern by Retinoic Acid....Pages 313-324
Survey of Research Work on the Regeneration of Triturus Alpestris Forelimbs Treated with Vitamin A Palmitate....Pages 325-340
Effects of Vitamin A on Limb Regeneration in the Larval Axolotl, Ambystoma Mexicanum ....Pages 341-353
Vitamin A Effect on Limb Regeneration: Studies on the Tadpoles of Anuran Amphibians....Pages 355-370
Front Matter....Pages 375-375
Position-Dependent Growth Control and Pattern Formation in Limb Regeneration....Pages 377-390
Supernumerary Limbs Developing after Small Angle Dislocations of the Limb Bud of the Newt....Pages 391-398
Experimental Analysis of Intercalary Limb Regeneration Capacity in Urodeles....Pages 399-408
Forelimb Regeneration in Reference with Hindlimb Regeneration in Stages of the Egyptian Toad, Bufo Regularis Reuss....Pages 409-416
Experimental Analysis of Mouse Limb Development In Situ ....Pages 417-417
Front Matter....Pages 375-375
Regeneration and Morphogenesis....Pages 419-434
Pattern Regeneration in an Insect Segment....Pages 435-446
Regeneration and Morphogenesis in the Feather Star Arm....Pages 447-460
Intercalary Regeneration and Supernumerary Limbs after Proximal or Distal Transposition of the Developing Limb Bud of the Anuran Bufo Bufo in Contralateral Transplantations....Pages 461-464
Digit Regeneration in Triturus Cristatus after Pattern Transforming Interventions....Pages 465-469
Ontogenesis and Regeneration of Embryonic Hindlimb Bud of Anuran Amphibian (Bufo) after Transplantation on the Tadpole Tail....Pages 471-478
The Effects of 4-Nitroquinoline-N-Oxide (4NQO) at Different Stages of Triturus Limb Regeneration....Pages 479-482
General Discussion....Pages 489-493
Back Matter....Pages 495-501

✦ Subjects

Developmental Biology;Animal Anatomy / Morphology / Histology;Plant Sciences;Animal Physiology;Biophysics and Biological Physics