## BACKGROUND. There is debate over whether the recent increases seen in prostate cancer are due to lead-time bias from screening, or identification of clinically insignificant lesions. METHODS. Population-based incidence rates for 1973-1996 were calculated, based on the Surveillance, Epidemiology,
Recent trends in prostate cancer mortality show a continuous decrease in several countries
โ Scribed by Christine Bouchardy; Gerald Fioretta; Elisabetta Rapiti; Helena Maria Verkooijen; Charles Henry Rapin; France Schmidlin; Raymond Miralbell; Roberto Zanetti
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- French
- Weight
- 503 KB
- Volume
- 123
- Category
- Article
- ISSN
- 0020-7136
No coin nor oath required. For personal study only.
โฆ Synopsis
Abstract
Prostate specific antigen (PSA) screening was introduced to detect prostate cancer at an early stage and to reduce prostate cancerโspecific mortality. Until results from clinical trials are available, the efficacy of PSA screening in reducing prostate cancer mortality can be estimated by surveillance of prostate cancer mortality trends. Our study analyzes recent trends in prostate cancer mortality in 38 countries. We used the IARCโWHO cancer mortality database and performed joinpoint analysis to examine prostate cancer mortality trends and identified 3 patterns. In USA, and to a lesser extent in Germany, Switzerland, Canada, France, Italy and Spain, prostate cancerโspecific mortality decreased to a level lower than before the introduction of PSA screening. In Australia, New Zealand, Austria, Finland, The Netherlands, Norway, United Kingdom, Hungary, Slovakia, Israel, Singapore, Sweden and Portugal, mortality from prostate cancer decreased but rates remain higher than before the introduction of PSA screening. Prostate cancer mortality continued to increase in Belgium, Denmark, Greece, Ireland, Bulgaria, Czech Republic, Belarus, Ukraine, Russian Federation, Romania, Poland, Argentina, Chile, Cuba, Mexico, Japan, China Hong Kong and the Republic of Korea. The trends in prostate cancer mortality rates in examined countries suggest that PSA screening may be effective in reducing mortality from prostate cancer. ยฉ 2008 WileyโLiss, Inc.
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