Recent Trends in Molecular Recognition

✍ Scribed by B. M. Trost (auth.), F. Diederich, H. Künzer (eds.)

• Publisher: Springer-Verlag Berlin Heidelberg
• Year: 1998
• Tongue: English
• Leaves: 254
• Series: Ernst Schering Research Foundation Workshop 26
• Edition: 1
• Category: Library

✦ Synopsis

Reasoning in terms of molecular recognition may be traced back to Emil Fischer, who practiced the art of chemistry at Humboldt University in Prussian Berlin a century ago. Today, it is clearly recognized that molecular recognition impacts and determines all life processes. It has become a key research field in both chemistry and biology and the emerging interface of what now is being called "chemical biology". The technological advances derived from this knowledge are particularly important, diverse, and directly evident in the pharmaceutical industry. Under the auspices of the Ernst Schering Research Foundation, a workshop held in Berlin in February 1998 addressed novel basic developments of potential relevance to drug research efforts. A balance of timely research topics in molecular recognition is presented in the lectures delivered by a multidisciplinary international panel of renowned scholars and documented in this volume.

✦ Table of Contents

Front Matter....Pages I-XIII
Designing Transition Metal Complexes for Molecular Recognition in Synthetic Transformations....Pages 1-24
REDOR NMR of Biological Solids: From Protein Binding Sites to Bacterial Cell Walls....Pages 25-52
Molecular and Dendritic Receptors for Small Biomolecules....Pages 53-80
Molecular Recognition of DNA by Ecteinascidin 743....Pages 81-95
New Tools for Drug Design Based on Protein Ligand Recognition Principles....Pages 97-118
Sequence-Specific Recognition of DNA and Control of Gene Expression by Oligonucleotide-Intercalator Conjugates....Pages 119-133
Combinatorial Nucleic Acid Libraries: The New World of Aptamers and Ribozymes....Pages 135-149
Sequence Specific Recognition of Double Stranded DNA by Peptide Nucleic Acid....Pages 151-167
Solid Phase Libraries of Glycopeptide Templates in the Study of Complex Oligosaccharide-Receptor Interactions....Pages 169-182
The Molecular Recognition of Saccharides and Glycoprotein-Inspired Materials....Pages 183-212
Self-Organized Autocatalytic Chemical Networks and Molecular Ecosystems: Do They Provide the Experimental Tools for Modeling the Transition from Inanimate to Animate Chemistry?....Pages 213-238
Back Matter....Pages 239-246

✦ Subjects

Biochemistry, general; Pharmacology/Toxicology; Pharmacy