Recent study on radioiodination of [4-127I]iodoantipyrine via isotope-exchange in dry-states up-to melt
✍ Scribed by G. El-Shaboury; K. Farah
- Publisher
- Elsevier Science
- Year
- 1991
- Weight
- 299 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0883-2889
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✦ Synopsis
A recent study on the radioiodination of [4-127I]iodoantipyrine with Na131I via no-carrier-added isotope exchange in dry-states up-to melt at 160 degrees C using different inorganic ammonium salts as catalyst was described at different reaction conditions of concentrations and temperatures (100-160 degrees C). A radiochemical yield (%) up to 98.5 of pure [4-131I]iodoantipyrine was obtained in melt (at 160 degrees C) using di-ammonium hydrogen orthophosphate within 2-5 min. The reaction offers a good possibility to label [4-127I]iodoantipyrine with short-lived radioiodine isotopes with no substrate decomposition.