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Recent Progress in Understanding Activity Cliffs and Their Utility in Medicinal Chemistry

✍ Scribed by Stumpfe, Dagmar; Hu, Ye; Dimova, Dilyana; Bajorath, Jürgen

Book ID
120959202
Publisher
American Chemical Society
Year
2013
Tongue
English
Weight
992 KB
Volume
57
Category
Article
ISSN
0022-2623

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The success of any drug discovery project relies upon the quality of the lead that initiates the lead optimization process. What defines a ‘quality lead’, where these ‘quality leads’ come from and how one discovers them has been the subject of intense debate within the pharmaceutical industry, relie