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Recent progress in the computational prediction of aqueous solubility and absorption

✍ Scribed by Stephen R. Johnson; Weifan Zheng


Book ID
119986602
Publisher
American Association of Pharmaceutical Scientists
Year
2006
Tongue
English
Weight
248 KB
Volume
8
Category
Article
ISSN
1550-7416

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Computational-Regulatory Developments in
✍ G. Valsami; P. Macheras πŸ“‚ Article πŸ“… 2011 πŸ› Wiley (John Wiley & Sons) 🌐 English βš– 459 KB

## Abstract Early prediction of human intestinal absorption is important in selection of potential orally administered drugs. Various computational models for prediction of the fraction of dose absorbed, __Fa__, have been developed. In 1989, a sigmoidal relationship between __Fa__ and drug absorpti