Recent Progress in Atherosclerosis Research

✍ Scribed by N. Simionescu, A. Sima, A. Dobrian (auth.), A. Roessner, E. Vollmer (eds.)

• Publisher: Springer-Verlag Berlin Heidelberg
• Year: 1993
• Tongue: English
• Leaves: 260
• Series: Current Topics in Pathology 87
• Edition: 1
• Category: Library

✦ Synopsis

This monograph on recent progress in atherosclerosis research presents state-of-the art morphological investigations on the cells and their metabolism in the atherosclerotic plaque in situ. The spectrum of methods includes immunohistologic and immunoelectron microscopic investigations on the localization of apolipoproteins in the cells of the arterial intima, presenting new data on the lipoprotein metabolism in plaque. The collagen metabolism is analysed by in situ hybridization techniques for demonstrating the synthesis of different collagen types on the messenger RNA level. Concentrating on in situ investigations with sophisticated morpholocial methods, the widespread discussion on atherogenesis is focused on the arterial wall and its morphological alterations. As morphology remains the basis for understanding the pathogenesis of disease, the results presented here could be of interest not only to pathologists, but also to clinicians and researchers working in the field of biology of atherosclerosis.

✦ Table of Contents

Front Matter....Pages I-XI
Pathobiochemical Changes of the Arterial Wall at the Inception of Atherosclerosis....Pages 1-45
Angiogenic Processes in the Pathogenesis of Human Coronary Atherosclerosis....Pages 47-58
Differentiation and Role of Macrophages in the Early Human Atherosclerotic Plaque....Pages 59-71
Lipoprotein Receptors on Macrophages and Smooth Muscle Cells....Pages 73-123
In Situ Localization and Distribution Pattern of Apolipoproteins in Arterial Walls: A Comparative Study in Atherosclerosis and Renal Transplant Arteriopathy....Pages 125-162
Collagens in Atherosclerotic Vessel Wall Lesions....Pages 163-192
Metabolism of Fibromuscular and Atheromatous Plaques in an Experimental Model: Causal Mechanisms for the Development of Intimal Necrosis....Pages 193-221
Parallels Between Renal Transplant Arteriopathy and Atherosclerosis in Respect of Functional Morphology....Pages 223-251
Back Matter....Pages 253-258

✦ Subjects

Pathology