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Recent phase III trials of fluorouracil, irinotecan, and oxaliplatin as chemotherapy for metastatic colorectal cancer

✍ Scribed by Richard M. Goldberg; Sharlene Gill

Publisher
Springer
Year
2004
Tongue
English
Weight
204 KB
Volume
54
Category
Article
ISSN
0344-5704

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## BACKGROUND. The combination of 5-fluorouracil (5-FU), leucovorin (LV), and oxaliplatin (l-OHP) was shown to be both more active against metastatic colorectal carcinoma and better tolerated if the drug delivery rate was chronomodulated according to circadian rhythms rather than constant. This all