Recent insights into body weight control: From physiology to pathology
✍ Scribed by Dr Robert Krysiak; Bogusław Okopień; Dariusz Belowski; Andrzej Madej; Zbigniew Stanisław Herman
- Book ID
- 105360165
- Publisher
- John Wiley and Sons
- Year
- 2001
- Tongue
- English
- Weight
- 97 KB
- Volume
- 7
- Category
- Article
- ISSN
- 1075-2617
- DOI
- 10.1002/psc.354
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
Over the past several years, new modulators of feeding and body weight have been discovered, and our knowledge of the mechanisms and neurohumoral interactions between anorexigenic and orexigenic compounds has increased dramatically. This review aims to summarize the present knowledge of the role of leptin and several hypothalamic neuropeptides, such as neuropeptide Y (NPY), corticotropin‐releasing hormone (CRH) and melanocortins, in the regulation of appetite and body weight. It also presents the progress made in the design of interactions between leptin and hypothalamic peptides in the regulation of feeding. The role of these compounds in the pathogenesis of obesity in animals and humans, and their potential usefulness in the treatment of this disorder, are discussed. Copyright © 2000 European Peptide Society and John Wiley & Sons, Ltd.