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Recent highlights in the synthesis of highly functionalized pyrimidines

✍ Scribed by Radi, Marco; Schenone, Silvia; Botta, Maurizio


Book ID
111644823
Publisher
Royal Society of Chemistry
Year
2009
Tongue
English
Weight
345 KB
Volume
7
Category
Article
ISSN
1477-0520

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The synthesis of novel chiral 4,7-disubstituted-and 2,4,7-trisubstituted-1,6,8-trioxoperhydropyrazino[1,2-c]pyrimidines from suitably protected TrpC[CH(CN)NH]Asp pseudodipeptides is described. This synthesis involves the cyclization of the C[CH(CN)NH] pseudodipeptides, via catalytic hydrogenation an