Recent Developments in Peptide Drug Delivery to the Brain
β Scribed by Pardridge, William M.
- Book ID
- 114801820
- Publisher
- John Wiley and Sons
- Year
- 1992
- Tongue
- English
- Weight
- 941 KB
- Volume
- 71
- Category
- Article
- ISSN
- 0901-9928
No coin nor oath required. For personal study only.
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## Abstract Targeted delivery of a drug or gene to its site of action has clear therapeutic advantages by maximizing its therapeutic efficiency and minimizing its systemic toxicity. Generally, targeted drug or gene delivery is performed by loading a macromolecular carrier with an appropriate drug o
## Abstract Peptides and regulatory proteins hold great promise as therapeutic agents for the central nervous system (CNS). However, the bloodβbrain barrier (BBB) is a major obstacle to the delivery of these potential therapeutics to their site of action. We concentrate here on the vascular BBB, wh