Recent developments in linker design and application

✍ Scribed by A Jonathan Wills; Shankar Balasubramanian

• Publisher: Elsevier Science
• Year: 2003
• Tongue: English
• Weight: 221 KB
• Volume: 7
• Category: Article
• ISSN: 1367-5931
• DOI: 10.1016/s1367-5931(03)00035-8

✦ Synopsis

The linker connecting the solid support and the substrate is critical to the ultimate success of a solid-phase synthesis. The evolution of linker constructs continues, offering new approaches to the analysis, release and deconvolution of resin-bound material and allowing entry to new structural motifs.