✦ LIBER ✦

Recent development and potential use of µ- and κ-opioid receptor ligands in positron emission tomography studies

✍ Scribed by Gjermund Henriksen; Frode Willoch; Peter S. Talbot; Hans-Jürgen Wester

Publisher: John Wiley and Sons
Year: 2006
Tongue: English
Weight: 364 KB
Volume: 67
Category: Article
ISSN: 0272-4391
DOI: 10.1002/ddr.20161

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Quantitative non‐invasive imaging of target structures in the human central nervous system provided by positron emission tomography (PET) permits investigation of the relationship between molecular events and pharmacological effects in living humans. Due to their prominent role in opiate and stimulant drug misuse and dependence, as well as in nociceptive signaling, µ‐ and κ‐opioid receptors are potential targets for advances in neuro(psycho)pharmacological treatment of these illnesses and syndromes. In this review, we describe recent developments in specific positron emitting radiopharmaceuticals for these opioid receptor subclasses. Implications for further advances and clinical applications of the labeled ligands are discussed. Drug Dev. Res. 67:890–904, 2006. © 2007 Wiley‐Liss, Inc.

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