Recent Applications of Palladium-Catalyzed Coupling Reactions in the Pharmaceutical, Agrochemical, and Fine Chemical Industries
✍ Scribed by Christian Torborg; Matthias Beller
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 399 KB
- Volume
- 351
- Category
- Article
- ISSN
- 1615-4150
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✦ Synopsis
Palladium-catalyzed coupling reactions have become a central tool for the synthesis of biologically active compounds both in academia and industry. Most of these transformations make use of easily available substrates and allow for a shorter and more selective preparation of substituted arenes and heteroarenes compared to non-catalytic pathways. Notably, molecular-defined palladium catalysts offer high chemoselectivity and broad functional group tolerance. Considering these advantages, it is not surprising that several palladium-catalyzed coupling reactions have been implemented in the last decade into the industrial manufacture of pharmaceuticals and fine chemicals. In this review different examples from 2001-2008 are highlighted, which have been performed at least on a kilogram scale in the chemical and pharmaceutical industries. 1 Introduction 2 Heck-Mizoroki Reactions 3 Suzuki-Miyaura Reactions 4 Sonogashira-Hagihara Reactions 5 Carbonylations 6 Cyanations 7 Other Pd-Catalyzed C À C Cross-Coupling Reactions 8 Buchwald-Hartwig Aminations 9 Miscellaneous 10 Conclusions and Outlook