✦ LIBER ✦

Recent advances in the synthesis, design and selection of cysteine protease inhibitors

✍ Scribed by Alejandro Alvarez Hernandez; William R Roush

Publisher: Elsevier Science
Year: 2002
Tongue: English
Weight: 91 KB
Volume: 6
Category: Article
ISSN: 1367-5931
DOI: 10.1016/s1367-5931(02)00345-9

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✦ Synopsis

Inhibition of cysteine proteases is emerging as an important strategy for the treatment of a variety of human diseases. Intense efforts involving structure-based inhibitor design have been directed toward several cysteine proteases, including cathepsin K, calpain, human rhinovirus 3C protease and several parasitic cysteine protease targets. Other successful recent efforts have involved combinatorial synthesis and screening for identification of new inhibitor templates.

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