## Abstract An increase in the permeability of the outer mitochondrial membrane is central to apoptotic cell death, since it leads to the release of several apoptogenic factors, such as cytochrome c and Smac/Diablo, into the cytoplasm that activate downstream death programs. During apoptosis, the m
β¦ LIBER β¦
Recent advances in the development of anticancer agents targeting cell death inhibitors in the Bcl-2 protein family
β Scribed by Shangary, S; Johnson, D E
- Book ID
- 110055561
- Publisher
- Nature Publishing Group
- Year
- 2003
- Tongue
- English
- Weight
- 212 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0887-6924
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## Abstract ## Background This study evaluates whether taurolidine, a novel antibiotic agent, induces murine melanoma cell apoptosis in vitro and in vivo. ## Methods Murine melanoma cells (B16 4A5 and B16 F10) were treated with taurolidine (0β100 Β΅M) for 12 and 24 hr. Cell viability and apoptosi