Content:
Volume Editors
Page iii
Copyright
Page iv
List of Contributors
Pages v-vii
Preface
Pages ix-x
Anders Björklund, M. Angela Cenci
Chapter 1 - Identifying PD-causing genes and genetic susceptibility factors: Current approaches and future prospects
Pages 2-20
Thomas Gasser
Chapter 2 - The impact of genetic research on our understanding of Parkinson’s disease
Pages 21-41
Ian Martin, Valina L. Dawson, Ted M. Dawson
Chapter 3 - Unravelling the role of defective genes
Pages 43-57
Mark R. Cookson
Chapter 4 - What causes the death of dopaminergic neurons in Parkinson’s disease?
Pages 59-77
D. James Surmeier, Jaime N. Guzman, Javier Sanchez-Padilla, Joshua A. Goldberg
Chapter 5 - Intracellular signalling pathways in dopamine cell death and axonal degeneration
Pages 79-97
Robert E. Burke
Chapter 6 - Control of mitochondrial integrity in Parkinson’s disease
Pages 99-113
Cristofol Vives-Bauza, Maja Tocilescu, Rosa L.A. deVries, Dana M. Alessi, Vernice Jackson-Lewis, Serge Przedborski
Chapter 7 - Role of post-translational modifications in modulating the structure, function and toxicity of α-synuclein: Implications for Parkinson’s disease pathogenesis and therapies
Pages 115-145
Abid Oueslati, Margot Fournier, Hilal A. Lashuel
Chapter 8 - The role of dopamine in modulating the structure and function of striatal circuits
Pages 148-167
D. James Surmeier, Weixing Shen, Michelle Day, Tracy Gertler, Savio Chan, Xianyong Tian, Joshua L. Plotkin
Chapter 9 - Assemblies of glutamate receptor subunits with post-synaptic density proteins and their alterations in Parkinson’s disease
Pages 169-182
Fabrizio Gardoni, Veronica Ghiglieri, Monica di Luca, Paolo Calabresi
Chapter 10 - Pathophysiological roles for purines: Adenosine, caffeine and urate
Pages 183-208
Micaela Morelli, Anna R. Carta, Anil Kachroo, Michael A. Schwarzschild
Chapter 11 - Maladaptive striatal plasticity in l-DOPA-induced dyskinesia
Pages 209-233
M. Angela Cenci, Christine Konradi
Chapter 12 - Effects of GPi and STN inactivation on physiological, motor, cognitive and motivational processes in animal models of Parkinson’s disease
Pages 235-258
Christelle Baunez, Paolo Gubellini
Chapter 13 - Computational physiology of the basal ganglia in Parkinson’s disease
Pages 259-273
Michal Rivlin-Etzion, Shlomo Elias, Gali Heimer, Hagai Bergman
Chapter 14 - Neurocomputational models of motor and cognitive deficits in Parkinson’s disease
Pages 275-297
Thomas V. Wiecki, Michael J. Frank
Subject Index
Pages 299-320
