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Recent advances in heme-protein sensors

✍ Scribed by Michael K Chan

Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
330 KB
Volume
5
Category
Article
ISSN
1367-5931

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✦ Synopsis

In recent years, an increasing number of proteins have been discovered which utilize heme cofactors to sense oxygen, carbon monoxide and nitric oxide. The identification and characterization of these proteins are revising our understanding of heme-mediated allostery first established in the early 1960s. Biochemical and structural studies are revealing new mechanisms for heme-driven conformational changes distinct from the classical hemoglobin model.

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