IgG and IgM class insulin autoantibodies were measured by an enzyme-linked immunosorbent assay in sera from members of the Barts-Windsor-Middlesex prospective family study for Type I (insulin-dependent) diabetes. One hundred and twelve individuals from 28 families were selected for study on the basi
Recent advances in diabetology: diabetic dermopathy, autoantibodies in the prediction of the development of type 1 diabetes, and islet cell transplantation and inhaled insulin as treatment for diabetes
β Scribed by K. A. Finucane; C. B. Archer
- Book ID
- 108694188
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- English
- Weight
- 96 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0307-6938
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Genetic determination as well as prospective analysis of islet cell autoantibodies and autoantibodies to insulin were conducted in a population of 479 first degree relatives of 174 Type 1 (insulin-dependent) diabetic patients. Analysis of HLA haplotypes within families illustrated the high frequency
Factors associated with diabetes onset were analysed for their predictive value in 708 first-degree relatives of Type 1 (insulin-dependent) diabetic patients including 374 parents and 308 siblings of Type i diabetic patients. Relatives were prospectively followed for 2 304 subject years with blood s
To evaluate the behaviour and predictive value of islet cell and insulin autoantibodies in patients with organ-specific autoimmune diseases, we followed 21 non-diabetic subjects for a mean period of 84 +/- 27 months. Ten patients were persistently seropositive for complement-fixing islet cell antibo