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Recent advances in and therapeutic potential of muscle-derived stem cells

✍ Scribed by Kristine O'Brien; Kristina Muskiewicz; Emanuela Gussoni

Publisher
John Wiley and Sons
Year
2002
Tongue
English
Weight
172 KB
Volume
85
Category
Article
ISSN
0730-2312

No coin nor oath required. For personal study only.

✦ Synopsis

Over the past few years, issues related to the commitment and potential of reservoir precursor cells that reside in most tissues have been revisited. Many reports have documented either plasticity or de-differentiation of a number of precursor cells isolated from several tissues, including bone marrow, brain, and skeletal muscle. These findings have challenged the dogma that mononuclear cells derived from adult, post-mitotic tissues can differentiate and contribute only to the tissue from which they originate. Thus, much current research in stem cells is testing the therapeutic potential of these cells to deliver normal genes and their encoded proteins into damaged or injured tissues. This review will focus on muscle-derived precursor cells and their apparently heterogeneous nature and summarize some of the most recent findings and hypotheses on their characterization and practical use.

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