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Rebound psychosis: Effect of discontinuation of antipsychotics in Parkinson's disease

✍ Scribed by Hubert H. Fernandez; Martha E. Trieschmann; Michael S. Okun

Publisher: John Wiley and Sons
Year: 2004
Tongue: English
Weight: 44 KB
Volume: 20
Category: Article
ISSN: 0885-3185
DOI: 10.1002/mds.20260

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✦ Synopsis

Abstract

To determine whether psychiatrically stable patients with a history of drug‐induced psychosis could be successfully weaned off their antipsychotic drug, we offered consecutive Parkinson disease (PD) patients on quetiapine or clozapine, who were free of any on‐going psychosis, to be slowly weaned off their antipsychotic drug. Before the study was aborted 6 PD patients (mean age, 78 years) with an average antipsychotic exposure of 20 months (5 on quetiapine, 1 on clozapine) were enrolled. After the antipsychotic agent was discontinued, psychosis recurred in 5 of 6 patients. In 3 patients the “rebound psychosis” was worse than the original psychotic episode and required subsequent higher antipsychotic medication doses. © 2004 Movement Disorder Society

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