Rebeccamycin and Staurosporine Biosynthesis: Insight into the Mechanisms of the Flavin-Dependent Monooxygenases RebC and StaC

An insight into the mechanism of cytotox

An insight into the mechanism of cytotoxicity of ricin to hepatoma cell: Roles of Bcl-2 family proteins, caspases, Ca2+-dependent proteases and protein kinase C

✍ Rong-gui Hu; Qi-wei Zhai; Wang-yi Liu; Xin-yuan Liu 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 343 KB

## Abstract The ability of ricin, a type II ribosome‐inactivating protein, to induce hepatoma cell (BEL7404) to apoptosis in vitro was examined by fluorescence microscopy, flow cytometry, and DNA fragmentation assay. As a Bcl‐2 lacking model, BEL7404 bore unique advantage to study the effect of ove