*A Comprehensive Guide to Toxicology in Preclinical Drug Development* is a resource for toxicologists in industry and regulatory settings, as well as directors working in contract resource organizations, who need a thorough understanding of the drug development process. Incorporating real-life case
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Reassessing the two-year rodent carcinogenicity bioassay: A review of the applicability to human risk and current perspectives
โ Scribed by Marone, Palma Ann; Hall, William C.; Hayes, A. Wallace
- Book ID
- 123385951
- Publisher
- Elsevier Science
- Year
- 2014
- Tongue
- English
- Weight
- 493 KB
- Volume
- 68
- Category
- Article
- ISSN
- 0273-2300
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The dermal Tg.AC transgenic mouse model has been proposed as a potential alternative to the conventional (e.g. oral, dermal, parenteral, inhalation, etc.) 2-year rodent bioassay for detecting chemical carcinogenicity. The present study was designed to address a number of technical aspects of this mo