Reassessing the TARBP2 mutation rate in hereditary nonpolyposis colorectal cancer
✍ Scribed by Garre, Pilar; Pérez-Segura, Pedro; Díaz-Rubio, Eduardo; Caldés, Trinidad; de la Hoya, Miguel
- Book ID
- 109918113
- Publisher
- Nature Publishing Group
- Year
- 2010
- Tongue
- English
- Weight
- 91 KB
- Volume
- 42
- Category
- Article
- ISSN
- 1061-4036
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In hereditary nonpolyposis colorectal cancer (HNPCC), the majority of reported mutations are dispersed throughout the 35 exons of the two principal susceptibility genes, MLH1 and MSH2, and because of this complexity, rapid mutation screening methods are required. The aim of this study was to evaluat
Communicated by Sauiu L.C. Woo We examined 18 unrelated individuals who have colorectal cancer or cancers associated with the HNPCC syndrome and have a family history of cancer for mutations in exon 13 of the hMSH2 gene. Two of the 18 individuals had the same previously unreported single-base delet