𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Rearrangement of the neoplasia-associated gene HMGIC in synovia from patients with osteoarthritis

✍ Scribed by Karin Broberg; Mattias Höglund; Janusz Limon; Anders Lindstrand; Sören Toksvig-Larsen; Nils Mandahl; Fredrik Mertens

Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
83 KB
Volume
24
Category
Article
ISSN
1045-2257

No coin nor oath required. For personal study only.

✦ Synopsis

The occurrence of clonal chromosome aberrations in short-term cultures from synovia, osteophytes, and cartilage from patients with osteoarthritis (OA) was recently reported. Among these aberrations, a recurrent involvement of chromosome bands 12q13-15 in structural rearrangements was detected in both synovia and osteophytes. Chromosomal abnormalities of 12q13-15 are frequent among malignant and benign mesenchymal tumors, and it was recently demonstrated that the molecular target in these neoplasms is the HMGIC gene. In this study, we show by fluorescence in situ hybridization that HMGIC was disrupted by rearrangements of 12q15 in synovia from two patients with OA. The finding of HMGIC rearrangement in a lesion that is not traditionally regarded as neoplastic not only widens the spectrum of disorders that may be associated with altered function of this gene, but also provides further support for the notion that genetically rearranged cell populations are part of the OA process.

📜 SIMILAR VOLUMES

Variation at the ANP32A gene is associat
Variation at the ANP32A gene is associated with risk of hip osteoarthritis in women
✍ Ana M. Valdes; Rik J. Lories; Joyce B. van Meurs; Hanneke Kerkhof; Sally Doherty 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 195 KB 👁 2 views

## Abstract ## Objective The ANP32A gene encodes a tumor suppressor molecule that plays a regulatory role in apoptosis and interferes with canonical Wnt signaling in vitro. We undertook this study to test whether genetic variation at ANP32A was associated with osteoarthritis (OA) in women. ## Met

Estrogen receptor α gene haplotype is as
Estrogen receptor α gene haplotype is associated with radiographic osteoarthritis of the knee in elderly men and women
✍ Arjan P. Bergink; Joyce B. van Meurs; John Loughlin; Pascal P. Arp; Yue Fang; Al 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 100 KB 👁 1 views

## Abstract ## Objective Genetic influences have been shown to play an important role in the etiology of osteoarthritis (OA), but the genes involved are ill‐defined. We studied the association between polymorphisms in the estrogen receptor α (ERα) gene and the prevalence of radiographic OA of the