Since the identification of the breast and ovarian cancer susceptibility genes BRCA1 and BRCA2, a large number of different germline mutations in both genes have been found by conventional PCR-based mutation detection methods. Complex germline rearrangements such as those reported in the BRCA1 gene
✦ LIBER ✦
Real-time PCR-based gene dosage assay for detecting BRCA1 rearrangements in breast–ovarian cancer families
✍ Scribed by M Barrois; I Bièche; S Mazoyer; M-H Champème; B Bressac-de Paillerets; R Lidereau
- Book ID
- 110725643
- Publisher
- John Wiley and Sons
- Year
- 2004
- Tongue
- English
- Weight
- 604 KB
- Volume
- 65
- Category
- Article
- ISSN
- 0009-9163
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Recent studies have revealed a significant proportion of BRCA1 exon deletions or duplications in breast-ovarian cancer families with high probability of BRCA1- or BRCA2-linked predisposition, in which mutations of these genes have not been found. The difficulty of detecting such heterozygous rearran