Real-time monitoring of radiofrequency ablation of rabbit liver by respiratory-gated quantitative temperature MRI
✍ Scribed by Matthieu Lepetit-Coiffé; Bruno Quesson; Olivier Seror; Erik Dumont; Brigitte Le Bail; Chrit T. W. Moonen; Hervé Trillaud
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- English
- Weight
- 572 KB
- Volume
- 24
- Category
- Article
- ISSN
- 1053-1807
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
Purpose
To evaluate the feasibility and precision of magnetic resonance imaging (MRI) thermometry for monitoring radiofrequency (RF) liver ablation in vivo and predicting the size of the ablation zone.
Materials and Methods
At 1.5T, respiratory‐triggered real‐time MR temperature mapping (the proton resonance frequency (PRF) method) was used to monitor RF ablation in rabbit liver (N = 6) under free breathing. The size of the ablation zones, as assessed by histological analyses, was compared with that predicted from MR thermal dose (TD) maps or derived from conventional T1‐weighted (T1w), T2‐weighted (T2w), and T1w gadolinium (Gd)‐enhanced (T1w‐Gd) images acquired immediately after the ablation, and on days 4 and 8 postprocedure.
Results
MR temperature uncertainty remained under 1–2°C even during RF deposition. The TD maps were shown to be more predictive and precise than the other MR images, with an average predictive precision for the final ablation zone size of about 1 mm as compared to the histologically proven lesion on day 8.
Conclusion
Quantitative temperature MRI during RF ablation is feasible and offered a precise indication of the ablation zone size in this preclinical study based on the lethal dose threshold. J. Magn. Reson. Imaging 2006. © 2006 Wiley‐Liss, Inc.