Real time monitoring of laser-induced thermal changes in cartilage in vitro by using snapshot FLASH
✍ Scribed by Peter M. Jakob; Christian Hendrich; Thomas Breitling; Achim Schäfer; Astrid Berden; Axel Haase
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- English
- Weight
- 465 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0740-3194
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✦ Synopsis
Abstract
Snapshot FLASH imaging has been applied to study the spatial and temporal spreading of thermal changes caused by a Holmium:YAG laser in patella cartilage in vitro at 7 T. The temperature dependence of the proton resonance frequency was used to demonstrate the thermal energy deposition. A series of cartilage images, with a time resolution of 512 ms and a spatial resolution of 400 × 200 μm, showed dynamic changes of the temperature‐related image phase in the regions irradiated by the laser.
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Background and Objective: This in vivo study examines the validity of using fluorescence measurements of laser-induced release of temperature-sensitive, liposome-encapsulated dye for real-time monitoring of temperature and for prediction of tissue thermal damage. ## Study DesignlMaterials and Metho