✦ LIBER ✦

Real-time molecular and cellular analysis: the new frontier of drug discovery

✍ Scribed by D Lansing Taylor; Elizabeth S Woo; Kenneth A Giuliano

Publisher: Elsevier Science
Year: 2001
Tongue: English
Weight: 187 KB
Volume: 12
Category: Article
ISSN: 0958-1669
DOI: 10.1016/s0958-1669(00)00180-4

No coin nor oath required. For personal study only.

✦ Synopsis

The pharmaceutical industry is currently facing the challenge of maintaining increased efficiency and productivity while contending with a deluge of genomic and high-throughput screening data. To ease the bottlenecks at target validation and lead optimization, the industry must look to the living cell, the ultimate target of all drugs, as a source of new biological knowledge. This new 'cell-centric' perspective must integrate reagents that report on the state of molecular processes within the cell, automated detection and analysis of these processes, and cellular knowledge, building into a single platform.

📜 SIMILAR VOLUMES

ChemInform Abstract: Molecular Pharmacol

ChemInform Abstract: Molecular Pharmacologic Approaches to Functional Analysis of New Biological Target Molecules for Drug Discovery

✍ Akemichi Baba 📂 Article 📅 2008 🏛 John Wiley and Sons ⚖ 15 KB 👁 1 views

ChemInform Abstract: The Bioinorganic an

ChemInform Abstract: The Bioinorganic and Medicinal Chemistry of Carboranes — From New Drug Discovery to Molecular Imaging and Therapy

✍ Andrea F. Armstrong; John F. Valliant 📂 Article 📅 2008 🏛 John Wiley and Sons ⚖ 15 KB 👁 2 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v

RFLP analysis and allelic discrimination

RFLP analysis and allelic discrimination with real-time PCR using the human lactase persistence trait : A pair of molecular genetic investigations

✍ Kenneth M. Weinlander; David J. Hall; Elizabeth A. De Stasio 📂 Article 📅 2010 🏛 The American Society for Biochemistry and Molecula 🌐 English ⚖ 326 KB

Column selection and method development

Column selection and method development for the separation of nucleoside phosphotriester diastereoisomers, new potential anti-viral drugs. Application to cellular extract analysis

✍ J. F. Goossens; C. Foulon; A.-L. Villard; J.-Y. Puy; I. Lefebvre; C. Perigaud; C 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 261 KB

## Abstract Analytical HPLC methods using derivatized cellulose and amylose chiral stationary phases used in normal and reversed‐phase modes were developed for the diastereoisomeric separation of mononucleotide prodrugs (pronucleotides) of 3′‐azido‐2′,3′‐dideoxythymidine (AZT). The resolutions were

Toward the Discovery of Novel Anti-HIV D

Toward the Discovery of Novel Anti-HIV Drugs. Second-Generation Inhibitors of the Cellular ATPase DDX3 with Improved Anti-HIV Activity: Synthesis, Structure–Activity Relationship Analysis, Cytotoxicity Studies, and Target Validation

✍ Dr. Giovanni Maga; Dr. Federico Falchi; Dr. Marco Radi; Dr. Lorenzo Botta; Dr. G 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 924 KB

Diagnosis of clear cell sarcoma by real-

Diagnosis of clear cell sarcoma by real-time reverse transcriptase-polymerase chain reaction analysis of paraffin embedded tissues : Clinicopathologic and molecular analysis of 44 patients from the French sarcoma group

✍ Jean-Michel Coindre; Isabelle Hostein; Philippe Terrier; Corinne Bouvier-Labit; 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 307 KB 👁 2 views