Real time HR–MAS NMR: application in reaction optimization, mechanism elucidation and kinetic analysis for heterogeneous reagent catalyzed small molecule chemistry
✍ Scribed by Abhijeet Deb Roy; K. Jayalakshmi; Somnath Dasgupta; Raja Roy; Balaram Mukhopadhyay
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 324 KB
- Volume
- 46
- Category
- Article
- ISSN
- 0749-1581
- DOI
- 10.1002/mrc.2321
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✦ Synopsis
Abstract
A novel application of **i**n situ ^1^H high‐resolution magic angle spinning (HR–MAS) NMR technique for real‐time monitoring of H~2~SO~4~‐silica promoted formation of 2, 2‐disubstituted quinozolin‐4(3H)‐ones is reported. The detailed NMR spectroscopic data led to elucidation of the mechanism, reaction optimization, kinetics and quantitative analysis of the product accurately and efficiently. The translation of the optimized parameters obtained by ^1^H HR–MAS NMR in the wet laboratory provided similar results. It is proposed that ^1^H HR‐MAS has a potential utility for optimization of various organic transformations in solid supported catalyzed reactions. Copyright © 2008 John Wiley & Sons, Ltd.