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Ready Access to 6-Alkyl, 6-Phenyl, 5,6-Dialkyl, and 5-Alkyl-6-phenyl Substituted 1,2,3,4-Tetrahydroisoquinolines

✍ Scribed by Peter Nussbaumer; Thomas Dechat


Book ID
106214908
Publisher
Springer Vienna
Year
2001
Tongue
English
Weight
99 KB
Volume
132
Category
Article
ISSN
0026-9247

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πŸ“œ SIMILAR VOLUMES


Stereocontrolled Alkylation of Chiral Py
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Treatment of salts 1a-b with Grignard reagents gives, after reduction of the resulting unstable dihydropyridines 7, the tetrahydropyridines 8a-c, with modest selectivities but in very few steps and under practical conditions. Higher stereoand regioselectivities are obtained with salt 1c which gives

2,2β€²-DiΒ­bromo-3,3β€²,4,4β€²,5,5β€²,6,6β€²-octaΒ­m
✍ Karunadasa, Hemamala ;Leggett, Christina ;Wong, Shaun πŸ“‚ Article πŸ“… 2004 πŸ› International Union of Crystallography 🌐 English βš– 190 KB

The title compound, C 29 H 24 Br 2 , has crystallographic twofold rotation symmetry. The Br atom in the 2 position is disordered with the methyl group in the 6 position. The biphenyl bridge bond distance and the torsion angle between the rings are in good agreement with similar previously reported s