Ready Access to 6-Alkyl, 6-Phenyl, 5,6-Dialkyl, and 5-Alkyl-6-phenyl Substituted 1,2,3,4-Tetrahydroisoquinolines
β Scribed by Peter Nussbaumer; Thomas Dechat
- Book ID
- 106214908
- Publisher
- Springer Vienna
- Year
- 2001
- Tongue
- English
- Weight
- 99 KB
- Volume
- 132
- Category
- Article
- ISSN
- 0026-9247
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π SIMILAR VOLUMES
Treatment of salts 1a-b with Grignard reagents gives, after reduction of the resulting unstable dihydropyridines 7, the tetrahydropyridines 8a-c, with modest selectivities but in very few steps and under practical conditions. Higher stereoand regioselectivities are obtained with salt 1c which gives
The title compound, C 29 H 24 Br 2 , has crystallographic twofold rotation symmetry. The Br atom in the 2 position is disordered with the methyl group in the 6 position. The biphenyl bridge bond distance and the torsion angle between the rings are in good agreement with similar previously reported s