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Reactivity of antiinflammatory and superoxide dismutase active Cu(II)-salicylates

✍ Scribed by Ulrich Weser; Christoph Richter; Albrecht Wendel; Maged Younes

Publisher
Elsevier Science
Year
1978
Weight
723 KB
Volume
8
Category
Article
ISSN
0006-3061

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✦ Synopsis

Several thiosemicarbazone-metal compIexes inhibit the RNA dependent DNA polymerase and the transfonuing ability of Rous sarcoma virus. Some complexes are equally as active as the free l&and whereas the activity of others is greatly enhanced. The 2-forrnyl pyridiue thiosemicarbazone copper (II) complex is the most potent compound of this class that we tested. Some copper complexes of sahcyIaIdehyde derivatives are very active also, particularly N-n-butyl, N-u-hexyl and N-benzyBali4aIdimine: no nickel complex of any sahcyhddehyde compound is active. In addition, other metal ligands, such as dithizone, diacetyl his (mercaptoethylimine), N+utyl thiocarbamate, 0,O' dimethyl dithiophosphate, potassium dithiooxalate, and cis-Pt1*(NH~)2C12 were tested with varying results.

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