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Reactive oxygen species production and Bax/Bcl-2 regulation in honokiol-induced apoptosis in human hepatocellular carcinoma SMMC-7721 cells

✍ Scribed by Ling-Li Han; Li-Ping Xie; Ling-Hui Li; Xiao-Wen Zhang; Rong-Qing Zhang; Hong-Zhong Wang


Book ID
116454811
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
958 KB
Volume
28
Category
Article
ISSN
1382-6689

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## Abstract Hepatocellular carcinoma (HCC) is resistant to chemotherapy. Recently, however, several oxaliplatin‐based combinatorial treatments have shown a promising anti‐tumor activity in patients with HCC. Presently, we demonstrate that oxaliplatin triggers necrosis more than apoptosis in HepG2,