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Reactive oxygen species mediate angiotensin II induced PGE2 and PGI2 production in rat mesangial cells via transcriptional upregulation of cyclooxygenase-2

✍ Scribed by Edgar A. Jaimes; Run-Xia Tian; Leopoldo Raij

Book ID: 117602113
Publisher: Nature Publishing Group
Year: 2003
Tongue: English
Weight: 36 KB
Volume: 16
Category: Article
ISSN: 0895-7061
DOI: 10.1016/s0895-7061(03)00516-8

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## Abstract Osteopontin (OPN), also called cytokine Eta‐1, expressed in the myocardium co‐incident with heart failure plays an important role in post myocardial infarction (MI) remodeling by promoting collagen synthesis and accumulation. Angiotensin II (Ang II) and inflammatory cytokines are increa