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Reactions of the Diiron Enzyme Stearoyl-Acyl Carrier Protein Desaturase

✍ Scribed by Brian G. Fox; Karen S. Lyle; Corina E. Rogge

Publisher: John Wiley and Sons
Year: 2004
Weight: 17 KB
Volume: 35
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.200439275

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## Abstract Triclosan, a well‐known inhibitor of Enoyl Acyl Carrier Protein Reductase (ENR) from several pathogenic organisms, is a promising lead compound to design effective drugs. We have solved the X‐ray crystal structures of __Plasmodium falciparum__ ENR in complex with triclosan variants havi