Reactions of the blood system and stem cells in bleomycin-induced model of lung fibrosis
β Scribed by A. M. Dygai; E. G. Skurikhin; T. V. Andreeva; L. A. Ermolaeva; E. S. Khmelevskaya; O. V. Pershina; V. A. Krupin; A. M. Reztsova; I. E. Stepanova; V. E. Goldberg
- Publisher
- Springer US
- Year
- 2011
- Tongue
- English
- Weight
- 737 KB
- Volume
- 152
- Category
- Article
- ISSN
- 0007-4888
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract ## Objective Tissue fibrosis is a hallmark compromising feature of many disorders. In this study, we investigated the antifibrogenic effects of the histone deacetylase inhibitor trichostatin A (TSA) on cytokineβdriven fibrotic responses in vitro and in vivo. ## Methods Skin fibroblas
## Abstract In the multipleβdose bleomycinβhamster model of pulmonary fibrosis, combined treatment with taurine and niacin blocks the increase in lung collagen deposition. We investigated the effects of taurine and niacin on lung lysyl oxidase and type I collagenase activities in this model. Hamste
Taurine and niacin have been previously found to block the accumulation of collagen in lung in the multidose bleomycin hamster model of pulmonary fibrosis. Previous studies have found an increase in the pulmonary collagen cross-links dihydroxylysinonoroleucine (DHLNL) and hydroxypyridinium (OHP) in