Reactions of (RP)- and (SP)-tert-butylphenylphosphinobromidates and tert-butylphenylthionophosphinochloridates with heteroatom nucleophiles; preparation of P-chiral binol phosphinates and related compounds

✍ Scribed by Tin-Lok Au-Yeung; Ka-Yee Chan; Wai-Kuen Chan; Richard K Haynes; Ian D Williams; Lam Lung Yeung

• Book ID: 104211494
• Publisher: Elsevier Science
• Year: 2001
• Tongue: French
• Weight: 115 KB
• Volume: 42
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(00)01950-x

✦ Synopsis

Reaction of (R P )-and (S P )-tert-butylphenylphosphinobromidates and tert-butylphenylthionophosphinochloridates with metallated phenol and BINOL alkoxides, thioalkoxides, amides and enolates leading with clean inversion at phosphorus to phosphinates, phosphinothiolates and phosphinoamidates, and the corresponding thionophosphorus compounds are described.