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Reactions of organic anions. XLIII. Catalytic method for synthesis of glycidic nitriles in aqueous medium

✍ Scribed by A. Jończyk; M. Fedoryński; M. Ma̧kosza

Publisher
Elsevier Science
Year
1972
Tongue
French
Weight
131 KB
Volume
13
Category
Article
ISSN
0040-4039

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✦ Synopsis

Darzens condensation between d-halocarbanions and carbonyl compounds that leads to the formation of glycidic acid derivatives is useful tool in synthesis.

Generally the d-halocarbanions are generated by action of dry sodium alkoxides, amide, hydride or other such agents on cc-haloesters, nitriles, ketones etc. in strictly anhydrous organic solvent or liquid ammonia (1).

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✍ M. ąkosza; E. iałecka 📂 Article 📅 1971 🏛 Elsevier Science 🌐 French ⚖ 129 KB

We have observed, that the reaction of chloroform l/ or bromoform2' with olefins in the presence of 50% aqueous NaOH and triethylbenzylammonium chloride /TEBA/ ie a very convenient method for preparation of dichlorocyclopropane derivatives. Carbene is formed in the first stage of the reaction and it