Reactions of derivatives of anthranilic acid with 3-chloropropyl isocyanate
β Scribed by E. P. Papadopoulos
- Book ID
- 112127623
- Publisher
- Journal of Heterocyclic Chemistry
- Year
- 1984
- Tongue
- English
- Weight
- 309 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0022-152X
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π SIMILAR VOLUMES
## Abstract The triethylamineβcatalyzed reactions of methyl __N__β(cyanothioformyl)anthranilate (**1**) with isocyanates result in cyclization involving the cyano group to form methyl 2β(4βiminoβ2βoxoβ3βsubstitutedβ5βthioxoimiβdazolidinβ1βyl)benzoates (**4**). Ring closure at the ester carbonyl to
An efficient and practical synthesis of 3-substituted quinazolinediones is described. The protocol uses readily available isocyanates and anthranilic acids as precursors in a one-pot operation and has been demonstrated on >50 g scale. Isolation of the products via filtration directly from the reacti