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Reactions of cisplatin with cysteine and methionine at constant pH; a computational study

✍ Scribed by Zimmermann, Tomáš ;Burda, Jaroslav V.


Book ID
120589012
Publisher
Royal Society of Chemistry
Year
2010
Tongue
English
Weight
510 KB
Volume
39
Category
Article
ISSN
1477-9226

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The activity of platinum compounds is dependent on nucleophile substitution reactions. In this paper, we study the reactivity of L-met with carboplatin, oxaliplatin and cisplatin by following with HPLC-UV the concentration of L-met and by characterizing the resulting adducts with LC-MS. In the absen