Reactions of Arylaldehydes and N-Sulfonated Imines with Dimethyl Acetylenedicarboxylate Catalyzed by Nitrogen and Phosphine Lewis Bases.
✍ Scribed by Chao-Qun Li; Min Shi
- Publisher
- John Wiley and Sons
- Year
- 2004
- Weight
- 161 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0931-7597
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## Abstract A series of polyether dendritic chiral phosphine Lewis bases was synthesized, and successfully applied to the asymmetric aza‐Morita–Baylis–Hillman reaction of __N__‐sulfonated imines (__N__‐arylmethylidene‐4‐methylbenzenesulfonamides) with methyl vinyl ketone (MVK), ethyl vinyl ketone (
## Abstract In the aza‐Morita–BaylisHillman reaction of __N__‐sulfonated imines (__N__‐arylmethylidene‐4‐methylbenzenesulfonamides and others) with methyl vinyl ketone (MVK), we found that in the presence of a catalytic amount of the chiral phosphine Lewis bases (__R__)‐(−)‐6,6′‐bis[tris(3,3,4,4,5