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Reactions of amine drugs with sugars I. Reaction of amphetamine with aldoses, glycosylamines, and bisulfite

✍ Scribed by J. C. Griffin; G. S. Banker

Publisher
John Wiley and Sons
Year
1967
Tongue
English
Weight
383 KB
Volume
56
Category
Article
ISSN
0022-3549

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✦ Synopsis

Amphetamine bisulfite was reacted with D-glucose, D-rnannose, N-phenylisopropyl-D-mannosylarnine, and N-phenyl-D-mannosylamine. The effect of an aryl or alkyl amine as the amino substituent at C-1 of the aldose on the formation of amino sulfonates was investigated. Alkyl substitution was found to yield bisulfite addition products, while aryl substitution yielded amino sulfonates. Mannose amphetamine sulfonate and glucose amphetamine sulfonate were synthesized.

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