Reactions of 9-substituted guanines with bromomalondialdehyde in aqueous solution predominantly yield glyoxal-derived adducts

Reaction of HO. with Guanine Derivatives

Reaction of HO. with Guanine Derivatives in Aqueous Solution: Formation of Two Different Redox-Active OH-Adduct Radicals and Their Unimolecular Transformation Reactions. Properties of G(-H).

✍ Luis P. Candeias; Steen Steenken 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 189 KB 👁 2 views

The reaction of . OH with 2'deoxyguanosine yields two transient species, both identified as OH adducts (G . -OH), with strongly different reactivity towards O 2 , or other oxidants, or to reductants. One of these, identified as the OH adduct at the C-8 position (yield 17 % relative to . OH), reacts