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Reactions of 4-[Bis(2-chloroethyl)amino]benzenebutanoic Acid (Chlorambucil) with DNA

✍ Scribed by Diana Florea-Wang; Agnieszka J. Pawlowicz; Jari Sinkkonen; Leif Kronberg; Juhani Vilpo; Jari Hovinen


Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
192 KB
Volume
6
Category
Article
ISSN
1612-1872

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Reactions of {4-[Bis(2-chloroethyl)amino
✍ Diana Florea-Wang; Inna Ijäs; Kristo Hakala; Jorma Mattinen; Juhani Vilpo; Jari 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 246 KB

## Abstract Phenylacetic acid mustard (PAM; **2**), a major metabolite of the anticancer agent chlorambucil (CLB; **1**), was allowed to react with 2′‐deoxyadenosine (dA), 2′‐deoxyguanosine (dG), 2′‐deoxycytidine (dC), 2′‐deoxy‐5‐methylcytidine (dMeC), and thymidine (T) at physiological pH (cacodyl