Reactions of 2,2-dimethylaziridine-type
โ
David Lalka; W. J. Jusko; T. J. Bardos
๐
Article
๐
1975
๐
John Wiley and Sons
๐
English
โ 634 KB
Pharmacokinetic studies in dogs were performed with a series of three 2,2-dimethylaziridine antineoplastic agents. These alkylating agents were relatively unstable in all aqueous media, with half-lives of 9-15 min in whole canine blood. This finding indicates that the aziridine compounds are capable